Codon Evolution: Mechanisms and Models

Codon Evolution: Mechanisms and Models

English | ISBN: 019960116X | 2012 | 320 Pages | PDF | 3 MB

Codon-based models of evolution are a relatively new addition to the toolkit of computational biologists, and in recent years remarkable progress has been made in this area. The study of evolution at the codon level captures information contained in both amino acid and synonymous DNA substitutions. By combining these two types of information, codon analyses are more powerful than those of either amino acid or DNA evolution alone. This is a clear benefit for most evolutionary analyses, including phylogenetic reconstruction, detection of selection, ancestral sequence reconstruction, and alignment of coding DNA. Despite the theoretical advantages of codon based models, their relative complexity delayed their widespread use. Only in recent years, when large-scale sequencing projects produced sufficient genomic data and computational power increased, did their usage become more common.

In Codon Evolution, leading researchers in the field of molecular evolution provide the latest insights from codon-based analyses of genetic sequences. The first part of the book provides comprehensive coverage of the developments of various types of codon substitution models such as parametric and empirical models used in maximum likelihood as well as Bayesian frameworks. Subsequent chapters examine the use of codon models to infer selection and other applications of codon models to biological systems. The second part of the book focuses on codon usage bias. Both the underlying mechanisms as well as current methods to analyse codon usage bias are presented.

Download:

http://longfiles.com/4gw5bgd3qax9/Codon_Evolution_Mechanisms_and_Models.pdf.html

[Fast Download] Codon Evolution: Mechanisms and Models


Related eBooks:
Electroporation Protocols: Microorganism, Mammalian System, and Nanodevice Ed 3
Handbook of Intellectual Disabilities: Integrating Theory, Research, and Practice
Therapeutic Enzymes: Function and Clinical Implications
Oncolytic Viruses
Adaptive Digital Filters
50 Great Myths of Human Sexuality
Chemistry
Psychology's Misuse of Statistics and Persistent Dismissal of its Critics
Digital Signal Processing Using MATLAB (3rd edition)
Schaum's outline of digital signal processing
Single Molecule and Single Cell Sequencing
Global Health and Security
Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.