Gene Therapy: Principles and Challenges

InTAvE | 2015 | ISBN: 9535122215 9789535122210 | 216 Pages | PDF | 11 MB

This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. Both viral and non-viral vectors are extensively discussed.

Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy.
The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy.
A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.

1 Cancer Gene Therapy
2 Methods of Transfection with Messenger RNA Gene Vectors
3 Multifunctional Delivery Systems for Cancer Gene Therapy
4 Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors
5 AAV Biology, Infectivity and Therapeutic Use from Bench to Clinic
6 First Insights into Non-invasive Administration Routes for Non-viral Gene Therapy
7 Genetically Engineered Bacteria in Gene Therapy - Hopes and Challenges
8 Encapsulation of Transgenic Cells for Gene Therapy


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