Kinase Drug Discovery

Kinase Drug Discovery

English | 2011 | ISBN: 1849731748 | ISBN-13: 9781849731744 | 332 Pages | PDF | 7,7 MB

Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development.

Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experience in the industry of well over 200 years, which has resulted in a book of great interest to the kinase field and across drug discovery more generally. Readers will gain a real insight into the huge challenges and opportunities which this target class has presented drug discovery scientists. The many chapters cover a wide breadth of topics, are well written and include high quality colour and black and white images.

Topics covered include an outline of how medicinal chemistry has been able to specifically exploit this unique target class, along with reflections on the mechanisms of kinases inhibitors. Also covered is resistance to kinase inhibitors caused by amino acid mutations, case studies of kinase programs and reviews areas beyond protein kinases and beyond the human kinome. Also described are modern approaches to finding kinase leads and the book finishes with a reflection of how kinase drug discovery may progress over the coming years.

Download:

http://longfiles.com/xrtojz8vx87k/Kinase_Drug_Discovery_ebook3000.pdf.html

[Fast Download] Kinase Drug Discovery


Ebooks related to "Kinase Drug Discovery" :
Handbook of Sustainable Luxury Textiles and Fashion: Volume 2
Functionalization of Carborane via Carboryne Intermediates
Mechanism of Functional Expression of the Molecular Machines
Cycloadditions in Bioorthogonal Chemistry
Polymer Nanocomposites: Towards Multi-Functionality
Nuclear Magnetic Resonance Spectroscopy in Environmental Chemistry (Topics in Environmental Chemistr
Materials Innovations in an Emerging Hydrogen Economy
Introduction to Structural Chemistry
Choong Eui Song - Cinchona Alkaloids in Synthesis and Catalysis: Ligands, Immobilization and Organoc
Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation
Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.