Methylation: From DNA, RNA and Histones to Diseases and Treatment ed. by Anica Dricu

Methylation: From DNA, RNA and Histones to Diseases and Treatment ed. by Anica Dricu

ITAe | 2012 | ISBN: 9789535108818 | 310 Pages | PDF | 14 MB


The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area.

Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation.
The textbook provides background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.

Contents
Preface
Section 1 Gene Expression and Methylation
1 Breaking the Silence: The Interplay Between Transcription Factors and DNA Methylation
Section 2 DNA-Methyltransferases: Structure and Function in Eukaryotic and Prokaryotic System
2 Diverse Domains of (Cytosine-5)-DNA Methyltransferases: Structural and Functional Characterizati
3 Bifunctional Prokaryotic DNA-Methyltransferases
Section 3 Protein Arginine Methylation in Mammals
4 Deciphering Protein Arginine Methylation in Mammals
Section 4 Cancer Research Through Study of Methylation Cell Processes
5 Methylation in Tumorigenesis
6 Circulating Methylated DNA as Bio markers for Cancer Detection
7 DNA Methylation, Stem Cells and Cancer
8 DNA Methylation in the Pathogenesis of Head and Neck Cancer
Section 5 Bacteria, Viruses and Metals Methylation: Risk and Benefit for Human Health
9 Host-Mimicking Strategies in DNA Methylation for Improved Bacterial Transformation
10 Messenger RNA Cap Methylation in Vesicular Stomatitis Virus, a Prototype of Noní§ Segmented Negati
11 The Methylation of Metals and Metalloids in Aquatic Systems

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