Phosphodiesterase Methods and Protocols

Phosphodiesterase Methods and Protocols

2005-06-22 | ISBN: 1588293149, 1617374873 | PDF | 336 Pages | 5.71 MB

Adenosine 3 ,5 -cyclic monophosphate (cAMP) and guanosine 3 ,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal state. Their critical role in intracellular sign- ing has recently designated them as new therapeutical targets. Several leading pharmaceutical companies are searching and developing new therapeutic agents that would potently and selectively inhibit PDE isozymes, notably PDE4 and PDE5. Nevertheless, the precise mechanism and the contribution of the various PDE isozymes in modulating intracellular signaling remain to be established. The aim of Phosphodiesterase Methods and Protocols is to provide a palette of a variety of conceptual and technical approaches designed to solve qu- tions concerning the role of PDEs, and ultimately of their different variants, in physiological functions as well as their implications in several pathologies.


[Fast Download] Phosphodiesterase Methods and Protocols

Ebooks related to "Phosphodiesterase Methods and Protocols" :
Bioresource and Stress Management
Plant Proteostasis: Methods and Protocols
Spix's Macaw: The Race to Save the World's Rarest Bird
Wildlife in Your Garden: Planting and Landscaping to Create a Backyard Sanctuary
Modified Nucleic Acids
Dodging Extinction: Power, Food, Money, and the Future of Life on Earth
Molekulare Genetik (Auflage: 9)
Rapeseed: Chemical Composition, Production and Health Benefits
Exploring the World of Mammals
Networks in Cell Biology
Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.