Phosphoinositide 3-kinase in Health and Disease: Volume 1

Phosphoinositide 3-kinase in Health and Disease: Volume 1
Springer | 2010-09-30 | ISBN: 3642136621 | 280 pages | File type: PDF | 4 mb

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here

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