Targeting the Broadly Pathogenic Kynurenine Pathway

Targeting the Broadly Pathogenic Kynurenine Pathway

2015-11-19 | ISBN: 3319118692, 3319363212 | PDF | 430 Pages | 15.35 MB

Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway andvarious disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism.The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.


[Fast Download] Targeting the Broadly Pathogenic Kynurenine Pathway

Ebooks related to "Targeting the Broadly Pathogenic Kynurenine Pathway" :
Frontiers in Staphylococcus aureus
Paranasal Sinuses
Zooarchaeology in the Neotropics: Environmental diversity and human-animal interactions
Microbial Steroids
Control of Salmonella and Other Bacterial Pathogens in Low-Moisture Foods
Chittaranjan Kole, "Fruits and Nuts. Genome Mapping and Molecular Breeding in Plants"
Molecular and Quantitative Animal Genetics
Pesticide Toxicity to Non-target Organisms: Exposure, Toxicity and Risk Assessment Methodologies
Chemical Ligation: Tools for Biomolecule Synthesis and Modification
Biology by Raven
Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.